Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5175115 | 0.91 | MAOA (0.58) | HTR2ASLC6A4KCNH2MAOAMAOB | |
| Dimethylamine SCHEMBL27645655 | 0.83 | HTR2A (0.58) | HTR2ASLC6A4KCNH2MAPTSOS1 | |
| Dimethylamine SCHEMBL27666829 | 0.79 | SLC6A4 (0.58) | HTR2ASLC6A4KCNH2CYP1A2CYP2C9 | |
| SCHEMBL351854 | 0.78 | SOS1 (0.58) | L3MBTL1SOS1HSPB1MEN1KMT2A | |
| SCHEMBL9242729 | 0.78 | MAOA (0.74) | MAOAMAOBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6290683 | 0.78 | SOS1 (0.58) | L3MBTL1SOS1HSPB1MEN1KMT2A | |
| SCHEMBL457634 | 0.78 | MAOA (0.74) | MAOAMAOBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6289867 | 0.78 | SOS1 (0.58) | L3MBTL1SOS1HSPB1MEN1KMT2A | |
| SCHEMBL9777083 | 0.76 | HPGD (0.59) | L3MBTL1ALDH1A1HPGD | |
| SCHEMBL27435779 | 0.76 | MAOA (0.64) | HTR2ASLC6A4KCNH2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1878546-A | Combination comprising an alpha-2 delta ligand and an SSRI and/or SNRI for the treatment of depression and anxiety | WARNER LAMBERT CO (US) | 2006-12-13 | — | — | CN | claimed |