Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2764078 | 0.92 | MAPT (0.53) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL2763969 | 0.86 | ALDH1A1 (0.52) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL2766897 | 0.83 | MAPT (0.46) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL2765153 | 0.80 | KDM4E (0.48) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL2765386 | 0.80 | SLC29A1 (0.46) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL2764643 | 0.80 | KDM4E (0.70) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL2765833 | 0.80 | MAPT (0.47) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL2763747 | 0.78 | MAPT (0.51) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL2764406 | 0.77 | KDM4E (0.60) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL2765063 | 0.77 | MAPT (0.45) | MAPTKDM4EALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400515-B1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | KOWA CO (JP) | 2010-04-14 | — | — | EP | disclosed |
| EP-1400515-A1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6472386-B1 | Cyclic diamine compound with 5-membered ring groups | KOWA CO., LTD. (JP) | 2002-10-29 | — | — | US | disclosed |