Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.70 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | GFER | P55789 | 2/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.56 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2763969 | 0.85 | ALDH1A1 (0.52) | KDM4EALDH1A1TDP1RAB9AMAPT | |
| SCHEMBL6194691 | 0.84 | KDM4E (0.97) | KDM4EALDH1A1TDP1RAB9AMAPT | |
| Hydrochloric Acid SCHEMBL27195564 | 0.82 | KDM4E (1.00) | KDM4EALDH1A1TDP1RAB9AMAPT | |
| SCHEMBL2764078 | 0.82 | MAPT (0.53) | KDM4EALDH1A1TDP1MAPTLMNA | |
| SCHEMBL3373976 | 0.81 | KDM4E (0.72) | KDM4EALDH1A1TDP1RAB9AMAPT | |
| SCHEMBL2766572 | 0.81 | HTR7 (0.61) | KDM4EALDH1A1TDP1GAAHPGD | |
| SCHEMBL2764871 | 0.80 | MAPT (0.51) | KDM4EALDH1A1TDP1MAPTLMNA | |
| SCHEMBL2764406 | 0.79 | KDM4E (0.60) | KDM4EALDH1A1TDP1MAPTLMNA | |
| SCHEMBL2765833 | 0.79 | MAPT (0.47) | KDM4EALDH1A1TDP1MAPTLMNA | |
| SCHEMBL2765186 | 0.78 | HTR7 (0.57) | KDM4EALDH1A1TDP1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400515-B1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | KOWA CO (JP) | 2010-04-14 | — | — | EP | disclosed |
| EP-1400515-A1 | CYCLIC DIAMINE COMPOUND HAVING FIVE-MEMBERED CYCLIC GROUP | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6472386-B1 | Cyclic diamine compound with 5-membered ring groups | KOWA CO., LTD. (JP) | 2002-10-29 | — | — | US | disclosed |