Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 6/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | KLK7 | P49862 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854865 | 1.00 | PTGER4 (0.41) | PTGER4PTGER3PTGER2ALDH1A1L3MBTL1 | |
| SCHEMBL2852674 | 0.82 | ALDH1A1 (0.43) | PTGER4PTGER3PTGER2ALDH1A1L3MBTL1 | |
| SCHEMBL10210607 | 0.79 | PTGER4 (0.43) | PTGER4PTGER3PTGER2ALDH1A1KLK7 | |
| SCHEMBL10210608 | 0.78 | PTGER4 (0.52) | PTGER4PTGER3PTGER2 | |
| SCHEMBL2851506 | 0.77 | ALDH1A1 (0.37) | PTGER4PTGER3PTGER2ALDH1A1L3MBTL1 | |
| SCHEMBL27650289 | 0.75 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1KLK7POLBMEN1 | |
| SCHEMBL4995634 | 0.71 | PTGER4 (0.49) | PTGER4PTGER3PTGER2ALDH1A1TDP1 | |
| SCHEMBL4995626 | 0.71 | PTGER4 (0.49) | PTGER4PTGER3PTGER2ALDH1A1TDP1 | |
| SCHEMBL5733480 | 0.68 | PTGER4 (0.48) | PTGER4PTGER3PTGER2 | |
| SCHEMBL5733485 | 0.68 | PTGER4 (0.48) | PTGER4PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101921220-B | Pharmaceutical compositions for treating diseases with bone mass loss having EP4 agonist as the active ingredient | ONO PHARMACEUTICAL CO | 2013-05-22 | — | — | CN | disclosed |
| CN-1893977-B | By EP4Medicine with agonist as active component for treating diseases related to bone loss | ONO PHARMACEUTICAL CO | 2012-12-05 | — | — | CN | disclosed |
| CN-101921220-A | Treat the EP that contains with the bone mass loss diseases associated 4Agonist is as the pharmaceutical composition of activeconstituents | ONO PHARMACEUTICAL CO | 2010-12-22 | — | — | CN | disclosed |
| CN-1893977-A | By EP4Medicine with agonist as active component for treating diseases related to bone loss | ONO PHARMACEUTICAL CO (JP) | 2007-01-10 | — | — | CN | disclosed |