Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | KLK7 | P49862 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854865 | 0.75 | PTGER4 (0.41) | ALDH1A1L3MBTL1KLK7MEN1MAPT | |
| SCHEMBL27650286 | 0.75 | PTGER4 (0.41) | ALDH1A1L3MBTL1KLK7MEN1MAPT | |
| SCHEMBL2852674 | 0.75 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1KLK7MEN1MAPT | |
| SCHEMBL27936325 | 0.67 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1KLK7MEN1MAPT | |
| SCHEMBL697475 | 0.66 | KLK7 (0.48) | ALDH1A1L3MBTL1KLK7MEN1MAPT | |
| SCHEMBL27721022 | 0.66 | MEN1 (0.48) | ALDH1A1L3MBTL1KLK7MEN1MAPT | |
| SCHEMBL28157789 | 0.66 | MEN1 (0.51) | ALDH1A1L3MBTL1KLK7MEN1MAPT | |
| SCHEMBL4005674 | 0.65 | MAPT (0.50) | ALDH1A1L3MBTL1KLK7MEN1MAPT | |
| SCHEMBL1759107 | 0.65 | LMNA (0.68) | ALDH1A1L3MBTL1KLK7MEN1MAPT | |
| SCHEMBL14199978 | 0.65 | MEN1 (0.50) | ALDH1A1L3MBTL1KLK7MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101921220-B | Pharmaceutical compositions for treating diseases with bone mass loss having EP4 agonist as the active ingredient | ONO PHARMACEUTICAL CO | 2013-05-22 | — | — | CN | disclosed |
| CN-1893977-B | By EP4Medicine with agonist as active component for treating diseases related to bone loss | ONO PHARMACEUTICAL CO | 2012-12-05 | — | — | CN | disclosed |
| CN-101921220-A | Treat the EP that contains with the bone mass loss diseases associated 4Agonist is as the pharmaceutical composition of activeconstituents | ONO PHARMACEUTICAL CO | 2010-12-22 | — | — | CN | disclosed |
| CN-1893977-A | By EP4Medicine with agonist as active component for treating diseases related to bone loss | ONO PHARMACEUTICAL CO (JP) | 2007-01-10 | — | — | CN | disclosed |