Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31058340 | 0.86 | MEN1 (0.49) | MAPTALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL14535278 | 0.80 | ALDH1A1 (0.44) | MAPTALDH1A1POLBKDM4ECYP1A2 | |
| SCHEMBL8415367 | 0.79 | SCN9A (0.38) | MAPTALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL3957395 | 0.79 | SCN9A (0.47) | MAPTALDH1A1POLBKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL1016343 | 0.77 | MAPT (0.40) | MAPTALDH1A1POLBKDM4EKMT2A | |
| SCHEMBL31058287 | 0.76 | SCN9A (0.40) | MAPTALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL4043905 | 0.76 | NCF1 (0.44) | MAPTPOLBMEN1KMT2ACYP1A2 | |
| SCHEMBL6769390 | 0.74 | SCN9A (0.46) | MAPTALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL15916282 | 0.74 | SCN9A (0.46) | MAPTALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL2882677 | 0.74 | DDB1 (0.60) | MAPTMEN1KMT2ASCN9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100441571-C | Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors | GLAXO GROUP LTD (GB) | 2008-12-10 | — | — | CN | disclosed |
| CN-1852896-A | Quinoline and quinazoline derivatives having affinity for 5HT 1-type receptors | GLAXO GROUP LTD (GB) | 2006-10-25 | — | — | CN | disclosed |