Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | WDR5 | P61964 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL521828 | 0.79 | EGLN1 (0.56) | — | |
| SCHEMBL8150746 | 0.79 | LDHA (0.50) | ALDH1A1SMN1; SMN2MAPTKDM4ECYP1A2 | |
| SCHEMBL5808263 | 0.77 | SMN1; SMN2 (0.38) | LMNAAKT1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16624730 | 0.76 | SMN1; SMN2 (0.48) | LMNAWDR5AKT1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11233688 | 0.75 | LDHA (0.47) | LMNAPTPN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL29576853 | 0.74 | AKT1 (0.64) | LMNAAKT1KDM4EGPR3NPC1 | |
| SCHEMBL913394 | 0.74 | AKT1 (0.64) | LMNAAKT1KDM4EGPR3NPC1 | |
| SCHEMBL18648904 | 0.74 | AKT1 (0.46) | LMNAAKT1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL8789401 | 0.73 | POLB (0.44) | ALDH1A1SMN1; SMN2MAPTKDM4EHPGD | |
| SCHEMBL19055055 | 0.73 | AKT1 (0.44) | LMNAAKT1SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100398519-C | Tetracyclic benzamide derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORP (US) | 2008-07-02 | — | — | CN | disclosed |
| CN-1780624-A | Tetracyclic benzamide derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORP (US) | 2006-05-31 | — | — | CN | disclosed |