Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523283 | 0.78 | EGLN1 (0.51) | EGLN2KMT2A | |
| SCHEMBL27651389 | 0.77 | LMNA (0.45) | SMN1; SMN2NPC1AKT1TDP1ALDH1A1 | |
| SCHEMBL521828 | 0.76 | EGLN1 (0.56) | — | |
| SCHEMBL21610293 | 0.71 | TDP1 (0.43) | SMN1; SMN2NPC1AKT1TDP1ALDH1A1 | |
| SCHEMBL28911350 | 0.69 | EGLN1 (0.68) | EGLN2 | |
| SCHEMBL16624730 | 0.68 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1AKT1TDP1ALDH1A1 | |
| SCHEMBL17698006 | 0.67 | PLK1 (0.62) | SMN1; SMN2NPC1ALDH1A1KDM4ELMNA | |
| SCHEMBL28912438 | 0.67 | EGLN1 (0.59) | — | |
| SCHEMBL28558839 | 0.67 | EGLN1 (0.45) | ALDH1A1MAPTKMT2A | |
| SCHEMBL6852083 | 0.67 | NPC1 (0.56) | SMN1; SMN2NPC1ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006099610-A2 | METHODS OF IDENTIFYING THERAPEUTIC TARGETS FOR THE TREATMENT OF VULVOVAGINAL ATROPHY | WYETH (US) | 2006-09-21 | — | — | WO | claimed |