Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | SCN1A | P35498 | 2/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11227110 | 0.81 | LMNA (0.57) | LMNAALDH1A1MEN1KMT2ADHODH | |
| SCHEMBL27818669 | 0.80 | HNF4A (0.53) | LMNAALDH1A1MEN1KMT2ADHODH | |
| SCHEMBL2499425 | 0.77 | CYP11B1 (0.46) | LMNAALDH1A1MEN1KMT2AACHE | |
| SCHEMBL1231452 | 0.77 | BCAT2 (0.57) | PDK2SCN9A | |
| Hydrochloric Acid SCHEMBL19385254 | 0.76 | BCAT2 (0.56) | PDK2SCN9A | |
| SCHEMBL16673206 | 0.73 | PDK2 (0.50) | LMNAPDK2ALDH1A1MEN1KMT2A | |
| SCHEMBL16673136 | 0.72 | PDK2 (0.48) | LMNAPDK2MEN1KMT2AMAPT | |
| SCHEMBL16672840 | 0.72 | PDK2 (0.48) | LMNAPDK2ALDH1A1MEN1KMT2A | |
| SCHEMBL5837400 | 0.71 | TSHR (0.49) | LMNAALDH1A1MEN1KMT2AACHE | |
| SCHEMBL28930303 | 0.70 | IGF2BP2 (0.41) | LMNAALDH1A1DHODHL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1805945-A | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers | MERCK & CO INC (US) | 2006-07-19 | — | — | CN | disclosed |