Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | DHODH | Q02127 | 7/20 | 0.51 |
| ▸ | COMT | P21964 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27945860 | 0.82 | DHODH (0.51) | NPC1RAB9ADHODHTDP1KDM4E | |
| SCHEMBL3327536 | 0.81 | DHODH (0.50) | NPC1RAB9ADHODHTDP1KDM4E | |
| SCHEMBL6170224 | 0.81 | PIP4K2A (0.47) | NPC1RAB9ANFKB1CASP3NFKB2 | |
| SCHEMBL3946376 | 0.80 | DHODH (0.43) | NPC1RAB9ADHODHL3MBTL1MKNK1 | |
| SCHEMBL22230633 | 0.80 | DHODH (0.47) | NPC1RAB9ADHODHTDP1MAPT | |
| SCHEMBL24196102 | 0.80 | DHODH (0.43) | NPC1RAB9ANFKB1CASP3NFKB2 | |
| SCHEMBL15638509 | 0.80 | RAB9A (0.54) | NPC1RAB9ADHODHEGFRTDP1 | |
| SCHEMBL7662428 | 0.79 | MKNK1 (0.61) | DHODHCOMTSYKL3MBTL1MKNK1 | |
| SCHEMBL2459179 | 0.79 | DHODH (0.43) | NPC1RAB9ANFKB1CASP3NFKB2 | |
| SCHEMBL28047020 | 0.78 | PTGS2 (0.56) | NPC1RAB9ADHODHCOMTSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101152185-B | Use of heterocyclic compounds as SCCE inhibitors | AREXIS AB | 2010-12-08 | — | — | CN | disclosed |
| CN-100518740-C | Pharmaceutical use of heterocyclic compounds as SCCE inhibitors | AREXIS AB (SE) | 2009-07-29 | — | — | CN | disclosed |
| CN-101152185-A | Use of heterocyclic compounds as scce inhibitors | AREXIS AB (SE) | 2008-04-02 | — | — | CN | disclosed |
| CN-1802160-A | Use of heterocyclic compounds as SCCE inhibitors | AREXIS AB (SE) | 2006-07-12 | — | — | CN | disclosed |