Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27945860 | 0.82 | DHODH (0.51) | DHODHTDP1NPC1RAB9AMAPT | |
| SCHEMBL3327536 | 0.81 | DHODH (0.50) | DHODHTDP1NPC1RAB9AMAPT | |
| SCHEMBL3946376 | 0.80 | DHODH (0.43) | DHODHTDP1NPC1RAB9AMAPT | |
| SCHEMBL22230633 | 0.80 | DHODH (0.47) | DHODHTDP1NPC1RAB9AMAPT | |
| SCHEMBL27652759 | 0.80 | NPC1 (0.54) | DHODHTDP1NPC1RAB9AMAPT | |
| SCHEMBL15638509 | 0.80 | RAB9A (0.54) | DHODHTDP1NPC1RAB9AMAPT | |
| SCHEMBL2459179 | 0.79 | DHODH (0.43) | DHODHTDP1NPC1RAB9AMAPT | |
| SCHEMBL6170224 | 0.77 | PIP4K2A (0.47) | DHODHTDP1NPC1RAB9AMAPT | |
| SCHEMBL24196449 | 0.76 | CYP11B2 (0.47) | DHODHMAPTMKNK1MKNK2CYP2C19 | |
| SCHEMBL24196023 | 0.76 | DHODH (0.45) | DHODHTDP1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022008475-A1 | INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER | UNIVERSITE CLAUDE BERNARD LYON 1 (FR) | 2022-01-13 | — | — | WO | disclosed |