Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 8/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4183271 | 0.74 | CFTR (0.47) | FYNPIK3CAATRBRD4MAPT | |
| SCHEMBL4491543 | 0.74 | FYN (0.49) | FYNPIK3CAATRBRD4MAPT | |
| SCHEMBL28309475 | 0.68 | MEN1 (0.47) | MAPTMAPK1KDM4ENPC1ALDH1A1 | |
| SCHEMBL3512252 | 0.67 | GLA (0.59) | FYNPIK3CAATRBRD4MAPT | |
| SCHEMBL28137042 | 0.66 | ALDH1A1 (0.54) | FYNMAPTTSHRMAPK1ADORA3 | |
| SCHEMBL15086777 | 0.65 | FYN (0.51) | FYNPIK3CAATRMAPTALDH1A1 | |
| SCHEMBL2903376 | 0.65 | FYN (0.71) | FYNPIK3CAATR | |
| SCHEMBL3435546 | 0.65 | MAPT (0.47) | FYNBRD4MAPTTSHRMAPK1 | |
| SCHEMBL15425099 | 0.65 | CA1 (0.61) | FYNPIK3CAATRMAPTMAPK1 | |
| SCHEMBL28103869 | 0.64 | PTGS2 (0.45) | FYNBRD4MAPTTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1809559-A | Pyrazole derivatives as phosphodiesterase 4 inhibitors | MEMORY PHARM CORP (US) | 2006-07-26 | — | — | CN | claimed |
| CN-1809559-A | Pyrazole derivatives as phosphodiesterase 4 inhibitors | MEMORY PHARM CORP (US) | 2006-07-26 | — | — | CN | disclosed |