Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | SLC40A1 | Q9NP59 | 7/20 | 0.47 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28105358 | 0.83 | SLC40A1 (0.52) | MMP2TSHRSLC40A1NFKBIARELA | |
| SCHEMBL18434377 | 0.81 | SLC40A1 (0.49) | MMP2TSHRSLC40A1NFKBIARELA | |
| SCHEMBL5989423 | 0.77 | KDM1A (0.46) | COMTTOP2AHSD17B10KDM4EL3MBTL1 | |
| SCHEMBL1753429 | 0.76 | PTGDR2 (0.64) | — | |
| SCHEMBL27570425 | 0.76 | TSHR (0.68) | COMTMMP2CHRM1TSHRADRA1A | |
| SCHEMBL28105074 | 0.75 | TSHR (0.66) | COMTMMP2CHRM1TSHRADRA1A | |
| SCHEMBL1765579 | 0.74 | HSD17B10 (0.49) | TSHRTOP2ALMNAHSD17B10KDM4E | |
| SCHEMBL5094221 | 0.74 | MMP2 (0.47) | COMTMMP2CHRM1TSHRADRA1A | |
| SCHEMBL1282008 | 0.74 | CCR1 (0.75) | COMTMMP2CHRM1TSHRADRA1A | |
| SCHEMBL30184687 | 0.74 | CCR1 (0.75) | COMTMMP2CHRM1TSHRADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100575330-C | Novel compounds | ASTRAZENECA AB | 2009-12-30 | — | — | CN | claimed |
| CN-1791572-A | Novel compounds | ASTRAZENECA AB (SE) | 2006-06-21 | — | — | CN | claimed |
| CN-100575330-C | Novel compounds | ASTRAZENECA AB | 2009-12-30 | — | — | CN | disclosed |
| CN-1791572-A | Novel compounds | ASTRAZENECA AB (SE) | 2006-06-21 | — | — | CN | disclosed |