Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2073212 | 0.87 | DRD2 (0.60) | SIGMAR1S1PR5HRH3MEN1KMT2A | |
| SCHEMBL1519223 | 0.86 | MEN1 (0.69) | SIGMAR1S1PR5ACHELTA4HMEN1 | |
| SCHEMBL13236630 | 0.85 | S1PR5 (0.66) | S1PR5HRH3ACHEBACE1S1PR4 | |
| SCHEMBL2925566 | 0.85 | SIGMAR1 (0.60) | SIGMAR1S1PR5HRH3LTA4HMEN1 | |
| SCHEMBL6994717 | 0.85 | HTR2A (0.64) | SIGMAR1S1PR5KDM4E | |
| SCHEMBL24770743 | 0.85 | ALDH1A1 (0.65) | SIGMAR1S1PR5HRH3LTA4HMEN1 | |
| SCHEMBL12660139 | 0.85 | KDM4E (0.64) | SIGMAR1HRH3ACHEBACE1LTA4H | |
| Hydrochloric Acid SCHEMBL2551741 | 0.85 | MEN1 (0.68) | SIGMAR1S1PR5ACHELTA4HMEN1 | |
| SCHEMBL22483727 | 0.84 | KCNH2 (0.59) | S1PR5LTA4HMEN1TSHRKMT2A | |
| SCHEMBL4002837 | 0.82 | SIGMAR1 (0.59) | SIGMAR1S1PR5HRH3MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102056933-B | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase | JANSSEN PHARMACEUTICA NV | 2014-09-17 | — | — | CN | disclosed |
| CN-102056933-A | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase | JANSSEN PHARMACEUTICA NV | 2011-05-11 | — | — | CN | disclosed |
| CN-100591679-C | Benzimidazole, benzthiazole and benzoxazole derivatives and their use as lta4h modulators | JANSSEN PHARMACEUTICA NV | 2010-02-24 | — | — | CN | disclosed |
| CN-1860117-A | Benzimidazole, benzthiazole and benzoxazole derivatives and their use as lta4h modulators | JANSSEN PHARMACEUTICA NV (BE) | 2006-11-08 | — | — | CN | disclosed |
| CN-1856490-A | Benzimidazole, benzothiazole and benzoxazole derivatives and their use as LTA4H modulators | JANSSEN PHARMACEUTICA NV (BE) | 2006-11-01 | — | — | CN | disclosed |