Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Biguanide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 3/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA3 | P07451 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyguanidine SCHEMBL13673553 | 0.89 | CYP2D6 (0.55) | CYP2D6MAPK1SNCAF2PRSS1 | |
| Pimagedine SCHEMBL1551679 | 0.89 | CYP2D6 (0.55) | CYP2D6MAPK1SNCAF2PRSS1 | |
| Guanidine SCHEMBL811270 | 0.88 | CYP2D6 (0.61) | CYP2D6MAPK1SNCAF2PRSS1 | |
| SCHEMBL5459478 | 0.86 | CYP2D6 (0.47) | CYP2D6MAPK1SNCAF2PRSS1 | |
| SCHEMBL3884567 | 0.85 | CYP2D6 (0.55) | CYP2D6MAPK1SNCAF2PRSS1 | |
| Thiourea SCHEMBL1577311 | 0.85 | CYP2D6 (0.58) | CYP2D6MAPK1SNCAF2PRSS1 | |
| SCHEMBL7490964 | 0.83 | CYP2D6 (0.54) | CYP2D6MAPK1SNCAF2PRSS1 | |
| Urea SCHEMBL11794762 | 0.82 | ALDH1A1 (0.57) | CYP2D6MAPK1SNCAF2PRSS1 | |
| Hydrazine SCHEMBL8861759 | 0.82 | ALDH1A1 (0.58) | CYP2D6MAPK1SNCAF2PRSS1 | |
| Hno SCHEMBL3391939 | 0.82 | GAA (0.56) | CYP2D6MAPK1SNCAF2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1846694-B | Substituted aromatic radical biguanide compounds and the application of their medicine composition in preparing medicine for resisting malignant tumors | INSTITUTE OF HEMATOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2012-02-01 | — | — | CN | claimed |
| CN-1846694-A | Substituted aromatic radical biguanide compounds and the application of their medicine composition in preparing medicine for resisting malignant tumors | INST OF HEMATOLOGY CHINESE ACA (CN) | 2006-10-18 | — | — | CN | claimed |
| CN-1846694-B | Substituted aromatic radical biguanide compounds and the application of their medicine composition in preparing medicine for resisting malignant tumors | INSTITUTE OF HEMATOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2012-02-01 | — | — | CN | disclosed |
| CN-1846694-A | Substituted aromatic radical biguanide compounds and the application of their medicine composition in preparing medicine for resisting malignant tumors | INST OF HEMATOLOGY CHINESE ACA (CN) | 2006-10-18 | — | — | CN | disclosed |