Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pimagedine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 3/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA3 | P07451 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyguanidine SCHEMBL13673553 | 0.89 | CYP2D6 (0.55) | CYP2D6MAPK1SNCAF2PRSS1 | |
| Biguanide SCHEMBL27660583 | 0.89 | CYP2D6 (0.55) | CYP2D6MAPK1SNCAF2PRSS1 | |
| Guanidine SCHEMBL811270 | 0.88 | CYP2D6 (0.61) | CYP2D6MAPK1SNCAF2PRSS1 | |
| Hydrazinecarboxamide SCHEMBL5353072 | 0.87 | ALDH1A1 (0.50) | CYP2D6MAPK1SNCAF2PRSS1 | |
| SCHEMBL3884567 | 0.85 | CYP2D6 (0.55) | CYP2D6MAPK1SNCAF2PRSS1 | |
| Thiourea SCHEMBL1577311 | 0.85 | CYP2D6 (0.58) | CYP2D6MAPK1SNCAF2PRSS1 | |
| SCHEMBL7687975 | 0.84 | CYP2D6 (0.48) | CYP2D6MAPK1SNCAF2PRSS1 | |
| SCHEMBL7202460 | 0.84 | CYP2D6 (0.48) | CYP2D6MAPK1SNCAF2PRSS1 | |
| Phenolsulfonic Acid SCHEMBL1551831 | 0.83 | LMNA (0.65) | CYP2D6MAPK1ALDH1A1CA1CA2 | |
| SCHEMBL7490964 | 0.83 | CYP2D6 (0.54) | CYP2D6MAPK1SNCAF2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996040663-A1 | DI- AND TRI-AMINOGUANIDINES AND THEIR USE TO INHIBIT THE ADVANCED GLYCOSYLATION OF PROTEINS | ALTEON INC. (US) | 1996-12-19 | — | — | WO | claimed |
| EP-4637921-A1 | POLYMORPH OF PHENYL PYRROLE HYDRAZINE CARBOXIMIDAMIDE COMPOUND | SynAct Pharma ApS (DK) | 2025-10-29 | — | — | EP | disclosed |
| WO-2024133643-A1 | POLYMORPH OF PHENYL PYRROLE HYDRAZINE CARBOXIMIDAMIDE COMPOUND | SYNACT PHARMA APS (DK) | 2024-06-27 | — | — | WO | disclosed |
| US-9212402-B2 | Aldehyde scrubbing in crust leather and tanned leather | ROHM AND HAAS COMPANY (US) | 2015-12-15 | — | — | US | disclosed |
| EP-2169080-B1 | Aldehyde Scrubbing in Crust Leather and Tanned Leather | ROHM & HAAS (US) | 2011-04-27 | — | — | EP | disclosed |
| EP-2169080-A1 | Aldehyde Scrubbing in Crust Leather and Tanned Leather | Rohm and Haas Company (US) | 2010-03-31 | — | — | EP | disclosed |
| US-20100068541-A1 | Aldehyde scrubbing in crust leather and tanned leather | ROHM AND HAAS COMPANY | 2010-03-18 | — | — | US | disclosed |
| US-6991659-B2 | Production of tanned leather and products suitable therefore | CLARIANT FINANCE (BVI) LIMITED (VG) | 2006-01-31 | — | — | US | disclosed |
| EP-1362128-B1 | PRODUCTION OF TANNED LEATHER AND PRODUCTS SUITABLE THEREFORE | CLARIANT FINANCE BVI LTD (VG) | 2005-03-09 | — | — | EP | disclosed |
| US-20040074009-A1 | Production of tanned leather and products suitable therefore | CLARIANT FINANCE (BVI) LIMITED (VG) | 2004-04-22 | — | — | US | disclosed |
| EP-1362128-A1 | PRODUCTION OF TANNED LEATHER AND PRODUCTS SUITABLE THEREFORE | Clariant Finance (BVI) Limited (VG) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002059382-A1 | PRODUCTION OF TANNED LEATHER AND PRODUCTS SUITABLE THEREFORE | CLARIANT INTERNATIONAL LTD (CH) | 2002-08-01 | — | — | WO | disclosed |
| WO-1996040663-A1 | DI- AND TRI-AMINOGUANIDINES AND THEIR USE TO INHIBIT THE ADVANCED GLYCOSYLATION OF PROTEINS | ALTEON INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| US-5160655-A | Laundry detergents, storage stability | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1992-11-03 | — | — | US | disclosed |
| US-5108930-A | Deprotenization of biological sample, reacting it with pyridine aldehyde to form pyridine aldehyde-substituted hydrazone of corresponding aminoguanidine; isolation, chromatographic analysis for quantity | ALTEON INC. (US) | 1992-04-28 | — | — | US | disclosed |
| EP-0448228-A2 | Aminoguanidine assay and applications thereof | ALTEON INC. (US) | 1991-09-25 | — | — | EP | disclosed |