Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 5/20 | 0.68 |
| ▸ | EDNRB | P24530 | 3/20 | 0.48 |
| ▸ | EDNRA | P25101 | 3/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27664461 | 0.88 | SERPINE1 (0.66) | SERPINE1EDNRBEDNRAMAPK8MEN1 | |
| SCHEMBL4980145 | 0.88 | SERPINE1 (0.81) | SERPINE1EDNRBEDNRAMAPK8MEN1 | |
| SCHEMBL4982359 | 0.84 | SERPINE1 (0.92) | SERPINE1EDNRBEDNRAMAPK8 | |
| SCHEMBL4980302 | 0.81 | SERPINE1 (1.00) | SERPINE1EDNRBEDNRA | |
| SCHEMBL5419800 | 0.80 | SERPINE1 (0.66) | SERPINE1EDNRBEDNRAMAPK8ALDH1A1 | |
| SCHEMBL4986284 | 0.79 | SERPINE1 (0.57) | SERPINE1EDNRBEDNRAMAPK8POLB | |
| SCHEMBL4884301 | 0.77 | SERPINE1 (0.80) | SERPINE1EDNRBEDNRAMAPK8 | |
| SCHEMBL14117729 | 0.77 | SERPINE1 (0.56) | SERPINE1EDNRBEDNRAMAPK8ALDH1A1 | |
| SCHEMBL4887004 | 0.76 | SERPINE1 (1.00) | SERPINE1EDNRBEDNRAMAPK8MEN1 | |
| SCHEMBL5174020 | 0.76 | SERPINE1 (0.58) | SERPINE1EDNRBEDNRAMAPK8POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332521-B2 | Substituted indoles | WYETH (US) | 2008-02-19 | — | — | US | claimed |
| JP-2007506772-A | — | — | 2007-03-22 | — | — | JP | claimed |
| EP-1667970-A1 | HETEROCYCLIC- OR ARYLOXY, -THIO 0R -AMINO SUBSTITUTED INDOLES-2-CARBOXYLIC ACIDS OR ESTERS AS PAI-1 INHIBITORS | Wyeth (US) | 2006-06-14 | — | — | EP | claimed |
| US-20050119327-A1 | Substituted indoles | WYETH (US) | 2005-06-02 | — | — | US | claimed |
| WO-2005030716-A1 | HETEROCYCLIC- OR ARYLOXY, -THIO OR -AMINO SUBSTITUTED INDOLES-2-CARBOXYLIC ACIDS OR ESTERS AS PAI-1 | WYETH (US) | 2005-04-07 | — | — | WO | claimed |
| US-7332521-B2 | Substituted indoles | WYETH (US) | 2008-02-19 | — | — | US | disclosed |
| EP-1667970-A1 | HETEROCYCLIC- OR ARYLOXY, -THIO 0R -AMINO SUBSTITUTED INDOLES-2-CARBOXYLIC ACIDS OR ESTERS AS PAI-1 INHIBITORS | Wyeth (US) | 2006-06-14 | — | — | EP | disclosed |
| US-20050119327-A1 | Substituted indoles | WYETH (US) | 2005-06-02 | — | — | US | disclosed |
| WO-2005030716-A1 | HETEROCYCLIC- OR ARYLOXY, -THIO OR -AMINO SUBSTITUTED INDOLES-2-CARBOXYLIC ACIDS OR ESTERS AS PAI-1 | WYETH (US) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119327-A1 | Substituted indoles | IDO2, IDO1, TPH2 | SERPINE1 4772/4885EDNRB 895/4885EDNRA 518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.