Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 5/20 | 0.57 |
| ▸ | EDNRB | P24530 | 4/20 | 0.46 |
| ▸ | EDNRA | P25101 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4980145 | 0.81 | SERPINE1 (0.81) | SERPINE1EDNRBEDNRAPOLBMAPT | |
| SCHEMBL27664461 | 0.79 | SERPINE1 (0.66) | SERPINE1EDNRBEDNRAPOLBMAPK8 | |
| SCHEMBL4982128 | 0.79 | SERPINE1 (0.68) | SERPINE1EDNRBEDNRAPOLBTP53 | |
| SCHEMBL4982359 | 0.76 | SERPINE1 (0.92) | SERPINE1EDNRBEDNRAMAPK8PTGES | |
| SCHEMBL5419800 | 0.73 | SERPINE1 (0.66) | SERPINE1EDNRBEDNRAPOLBMAPK8 | |
| SCHEMBL4980302 | 0.72 | SERPINE1 (1.00) | SERPINE1EDNRBEDNRAPTGES | |
| SCHEMBL4887004 | 0.72 | SERPINE1 (1.00) | SERPINE1EDNRBEDNRAPOLBMAPT | |
| SCHEMBL4884301 | 0.71 | SERPINE1 (0.80) | SERPINE1EDNRBEDNRAMAPK8 | |
| SCHEMBL24472619 | 0.70 | SIRT2 (0.47) | MAPTTP53GAA | |
| SCHEMBL31271939 | 0.70 | SIRT2 (0.47) | MAPTTP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332521-B2 | Substituted indoles | WYETH (US) | 2008-02-19 | — | — | US | claimed |
| US-20050119327-A1 | Substituted indoles | WYETH (US) | 2005-06-02 | — | — | US | claimed |
| US-7332521-B2 | Substituted indoles | WYETH (US) | 2008-02-19 | — | — | US | disclosed |
| US-20050119327-A1 | Substituted indoles | WYETH (US) | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119327-A1 | Substituted indoles | IDO2, IDO1, TPH2 | SERPINE1 4772/4885EDNRB 895/4885EDNRA 518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.