Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | SPTLC2 | O15270 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27643397 | 0.92 | POLB (0.44) | POLBALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL5032648 | 0.92 | ALDH1A1 (0.48) | POLBALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL5032534 | 0.90 | NPC1 (0.44) | POLBALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL5035129 | 0.88 | TRPC3 (0.40) | POLBALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL27664741 | 0.87 | HTR2C (0.47) | POLBSPTLC2TRPC3TRPC6 | |
| SCHEMBL27643378 | 0.86 | HTR2C (0.49) | KMT2ATSHRNPC1RAB9A | |
| SCHEMBL27664673 | 0.86 | NPC1 (0.41) | ALDH1A1TSHRL3MBTL1NPC1RAB9A | |
| SCHEMBL27643379 | 0.86 | ALDH1A1 (0.42) | ALDH1A1KMT2ATSHRL3MBTL1NPC1 | |
| SCHEMBL27664668 | 0.85 | POLB (0.43) | POLBALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL5032473 | 0.84 | RAB9A (0.42) | ALDH1A1KMT2ANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | claimed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | claimed |
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | disclosed |