Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | TRPC3 | Q13507 | 4/20 | 0.41 |
| ▸ | TRPC6 | Q9Y210 | 4/20 | 0.41 |
| ▸ | SPTLC2 | O15270 | 6/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032534 | 0.92 | NPC1 (0.44) | HTR2CPOLB | |
| SCHEMBL5032544 | 0.91 | HTR2C (0.42) | HTR2CTRPC3TRPC6POLBLRRK2 | |
| SCHEMBL27643397 | 0.91 | POLB (0.44) | SPTLC2POLB | |
| SCHEMBL27643379 | 0.90 | ALDH1A1 (0.42) | HTR2CTRPC3TRPC6TP53PDE4B | |
| SCHEMBL27664673 | 0.90 | NPC1 (0.41) | HTR2CTRPC3TRPC6SPTLC2 | |
| SCHEMBL27643378 | 0.89 | HTR2C (0.49) | HTR2C | |
| SCHEMBL27664669 | 0.87 | POLB (0.44) | TRPC3TRPC6SPTLC2POLB | |
| SCHEMBL5034700 | 0.86 | RAB9A (0.38) | HTR2CTRPC3TRPC6LRRK2 | |
| SCHEMBL5035129 | 0.85 | TRPC3 (0.40) | TRPC3TRPC6SPTLC2TP53POLB | |
| SCHEMBL5032563 | 0.83 | ALDH1A1 (0.47) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | claimed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | claimed |
| CN-100509808-C | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |
| CN-1890236-A | Novel thiazole derivates | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | disclosed |