Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28251967 | 0.84 | KMO (0.41) | KMOELANECYP11B1CYP11B2POLB | |
| SCHEMBL2029059 | 0.82 | KMO (0.44) | KMOELANECYP11B1CYP11B2POLB | |
| SCHEMBL3923482 | 0.82 | KMO (0.39) | KMOELANECYP11B1CYP11B2POLB | |
| SCHEMBL1162916 | 0.82 | KMO (0.46) | KMOELANEPOLBHSD17B10TSHR | |
| SCHEMBL28094503 | 0.80 | CHEK1 (0.43) | KMOKMT2AALDH1A1MAPT | |
| SCHEMBL27690302 | 0.80 | HDAC8 (0.39) | KMOELANESLC22A12RAB9ANPC1 | |
| SCHEMBL27634812 | 0.80 | CHEK1 (0.54) | CYP11B1CYP11B2RAB9AKMT2AALDH1A1 | |
| SCHEMBL536315 | 0.79 | KMO (0.45) | KMOELANEPOLBHSD17B10TSHR | |
| SCHEMBL1854888 | 0.79 | KMO (0.44) | KMOELANEPOLBHSD17B10TSHR | |
| SCHEMBL31661024 | 0.78 | CYP11B1 (0.40) | KMOELANECYP11B1CYP11B2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102171192-A | Indazole compounds | ASAHI KASEI PHARMA CORP | 2011-08-31 | — | — | CN | claimed |
| CN-110300751-A | Tetra-substituted alkene compounds and their use for treating breast cancer | 卫材 R&D 管理有限公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-110214137-A | As αvThe indazole derivative of integrin antagonists | 百时美施贵宝公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-104837832-B | GDF-8 inhibitors | 里格尔药品股份有限公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-106458992-B | Pyridyl piperidine | 默克专利股份公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-106458992-A | Pyridyl piperidines | 默克专利股份公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-104755477-A | 2-aminopyridine compounds | MERCK PATENT GMBH | 2015-07-01 | — | — | CN | disclosed |
| CN-102171191-A | Indazole derivative | ASAHI KASEI PHARMA CORP | 2011-08-31 | — | — | CN | disclosed |
| CN-102171192-A | Indazole compounds | ASAHI KASEI PHARMA CORP | 2011-08-31 | — | — | CN | disclosed |
| CN-100558428-C | Calcitonin gene related peptide receptor antagonists | BRISTOL MYERS SQUIBB CO (US) | 2009-11-11 | — | — | CN | disclosed |
| CN-101489551-A | Aminoindazole urea derivatives | MERCK PATENT GMBH (DE) | 2009-07-22 | — | — | CN | disclosed |
| CN-101208094-A | Pharmacokinetic improved compounds | SURFACE LOGIX INC (US) | 2008-06-25 | — | — | CN | disclosed |
| CN-1917921-A | Calcitonin gene related peptide receptor antagonists | BRISTOL MYERS SQUIBB CO (US) | 2007-02-21 | — | — | CN | disclosed |