Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27664784 | 0.82 | KMO (0.41) | KMOKDM4EALDH1A1ELANECYP11B1 | |
| SCHEMBL2029059 | 0.80 | KMO (0.44) | KMOELANECYP11B1CYP11B2TSHR | |
| SCHEMBL19543143 | 0.79 | KMO (0.39) | KMOKDM4EALDH1A1ELANETSHR | |
| SCHEMBL31661024 | 0.79 | CYP11B1 (0.40) | KMOKDM4EALDH1A1ELANECYP11B1 | |
| SCHEMBL13994553 | 0.79 | CYP11B1 (0.40) | KMOKDM4EALDH1A1ELANECYP11B1 | |
| SCHEMBL1162916 | 0.79 | KMO (0.46) | KMOELANETSHRPOLBHSD17B10 | |
| SCHEMBL536315 | 0.77 | KMO (0.45) | KMOALDH1A1ELANETSHRPOLB | |
| SCHEMBL1854888 | 0.76 | KMO (0.44) | KMOELANETSHRPOLBHSD17B10 | |
| SCHEMBL19543121 | 0.76 | KMO (0.41) | KMOKDM4EELANETSHRPOLB | |
| SCHEMBL2363023 | 0.76 | ELANE (0.49) | KMOKDM4EALDH1A1ELANETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040701-A2 | AMINOINDAZOLE UREA DERIVATIVES | Merck Patent GmbH (DE) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008009335-A2 | AMINOINDAZOLE UREA DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-01-24 | — | — | WO | disclosed |