Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MLYCD | O95822 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27583942 | 0.83 | SIRT6 (0.60) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL27664839 | 0.82 | SLC6A2 (0.55) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL30198400 | 0.79 | SIRT6 (0.66) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL1203455 | 0.79 | SIRT6 (0.66) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL2627249 | 0.78 | MAPT (0.69) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL27895699 | 0.77 | ALDH1A1 (0.66) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL533010 | 0.77 | MAPT (0.66) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL15272176 | 0.77 | MAPT (0.66) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL14140324 | 0.76 | MEN1 (0.60) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL5165090 | 0.76 | MAPT (0.54) | KDM4EMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1989138-A | 2-Substituted-4-heteroaryl-pyrimidines useful in the treatment of proliferative diseases | CYCLACEL LTD (GB) | 2007-06-27 | — | — | CN | disclosed |