Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1126076 | 0.83 | MAPT (0.60) | MAPTKDM4EMEN1KMT2AHTR7 | |
| SCHEMBL3632512 | 0.82 | CTSK (0.60) | MAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL31232720 | 0.81 | HTR7 (0.56) | MAPTKDM4EMEN1KMT2AHTR7 | |
| SCHEMBL520396 | 0.81 | HTR7 (0.56) | MAPTKDM4EMEN1KMT2AHTR7 | |
| SCHEMBL2627249 | 0.81 | MAPT (0.69) | MAPTKDM4EMEN1KMT2AHTR7 | |
| Hydrochloric Acid SCHEMBL31232759 | 0.80 | HTR7 (0.58) | MAPTKDM4EMEN1KMT2AHTR7 | |
| SCHEMBL2658565 | 0.80 | POLB (0.56) | MAPTKDM4EMEN1KMT2AHTR7 | |
| SCHEMBL5779277 | 0.80 | MAPT (0.52) | MAPTKDM4EMEN1KMT2AHTR7 | |
| SCHEMBL2658558 | 0.80 | POLB (0.56) | MAPTKDM4EMEN1KMT2AHTR7 | |
| SCHEMBL2659435 | 0.80 | L3MBTL1 (0.61) | MAPTKDM4EMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756098-A2 | 2-SUBSTITUTED-4-HETEROARYL-PYRIMIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Cyclacel Limited (GB) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005116025-A2 | 2-SUBSTITUTED-4-HETEROARYL-PYRIMIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | CYCLACEL LIMITED (GB) | 2005-12-08 | — | — | WO | disclosed |