Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.47 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12184218 | 1.00 | RIPK1 (0.58) | RIPK1HSD11B1PRMT5WDR77TMEM97 | |
| SCHEMBL10002512 | 0.95 | RIPK1 (0.64) | RIPK1HSD11B1PRMT5WDR77EPHX2 | |
| SCHEMBL26984487 | 0.85 | TMEM97 (0.58) | RIPK1HSD11B1PRMT5WDR77TMEM97 | |
| SCHEMBL24365127 | 0.85 | FKBP1A (0.57) | RIPK1HSD11B1PRMT5WDR77EPHX2 | |
| SCHEMBL17114341 | 0.85 | RIPK1 (0.63) | RIPK1HSD11B1PRMT5WDR77TMEM97 | |
| SCHEMBL24365782 | 0.85 | RIPK1 (0.63) | RIPK1HSD11B1PRMT5WDR77TMEM97 | |
| SCHEMBL7469150 | 0.85 | RIPK1 (0.63) | RIPK1HSD11B1PRMT5WDR77TMEM97 | |
| SCHEMBL24367619 | 0.85 | FKBP1A (0.57) | RIPK1HSD11B1PRMT5WDR77EPHX2 | |
| SCHEMBL8303313 | 0.85 | TMEM97 (0.58) | RIPK1HSD11B1PRMT5WDR77TMEM97 | |
| SCHEMBL12536841 | 0.85 | RIPK1 (0.49) | RIPK1HSD11B1PRMT5WDR77EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1898234-A | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | INCYTE CORP (US) | 2007-01-17 | — | — | CN | disclosed |