Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.58 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26984487 | 1.00 | TMEM97 (0.58) | TMEM97SIGMAR1RIPK1HSD11B1PRMT5 | |
| SCHEMBL22721972 | 0.88 | TMEM97 (0.56) | TMEM97SIGMAR1RIPK1HSD11B1 | |
| SCHEMBL29540420 | 0.88 | TMEM97 (0.56) | TMEM97SIGMAR1RIPK1HSD11B1 | |
| SCHEMBL4033512 | 0.86 | TMEM97 (0.68) | TMEM97SIGMAR1 | |
| SCHEMBL27672000 | 0.85 | RIPK1 (0.58) | TMEM97SIGMAR1RIPK1HSD11B1PRMT5 | |
| SCHEMBL12184218 | 0.85 | RIPK1 (0.58) | TMEM97SIGMAR1RIPK1HSD11B1PRMT5 | |
| Water SCHEMBL27700641 | 0.85 | TMEM97 (0.67) | TMEM97SIGMAR1 | |
| Water SCHEMBL27740102 | 0.84 | TMEM97 (0.66) | TMEM97SIGMAR1 | |
| SCHEMBL24365782 | 0.83 | RIPK1 (0.63) | TMEM97SIGMAR1RIPK1HSD11B1PRMT5 | |
| SCHEMBL7469150 | 0.83 | RIPK1 (0.63) | TMEM97SIGMAR1RIPK1HSD11B1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862435-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-02-03 | — | — | EP | disclosed |
| EP-0862435-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997018813-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-05-29 | — | — | WO | disclosed |