Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.71 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.71 |
| ▸ | RAB9A | P51151 | 7/20 | 0.70 |
| ▸ | NPC1 | O15118 | 6/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | TP53 | P04637 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | STAT3 | P40763 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.61 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.61 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.61 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27672992 | 0.88 | HDAC1 (0.61) | HIF1AEPAS1RAB9ANPC1MAPK1 | |
| SCHEMBL27652919 | 0.88 | HDAC6 (0.57) | HIF1AEPAS1RAB9ANPC1MAPK1 | |
| SCHEMBL27672989 | 0.87 | TNF (0.62) | HIF1AEPAS1RAB9ANPC1MAPK1 | |
| SCHEMBL27652930 | 0.87 | TNF (0.62) | HIF1AEPAS1RAB9ANPC1MAPK1 | |
| SCHEMBL27673031 | 0.86 | NPC1 (0.54) | HIF1AEPAS1RAB9ANPC1MAPK1 | |
| SCHEMBL28759315 | 0.85 | HDAC1 (0.53) | HIF1AEPAS1RAB9ANPC1MAPK1 | |
| SCHEMBL27672993 | 0.84 | RAB9A (0.66) | HIF1AEPAS1RAB9ANPC1MAPK1 | |
| SCHEMBL21657710 | 0.83 | HIF1A (1.00) | HIF1AEPAS1RAB9ANPC1MAPK1 | |
| SCHEMBL8769811 | 0.83 | RAB9A (0.83) | HIF1AEPAS1RAB9ANPC1MAPK1 | |
| SCHEMBL21024443 | 0.82 | RAB9A (1.00) | HIF1AEPAS1RAB9ANPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1946395-A | 1H-thieno [2, 3-c ] pyrazole derivatives useful as kinase inhibitors | PHARMACIA ITALIA SPA (IT) | 2007-04-11 | — | — | CN | claimed |
| CN-1946395-A | 1H-thieno [2, 3-c ] pyrazole derivatives useful as kinase inhibitors | PHARMACIA ITALIA SPA (IT) | 2007-04-11 | — | — | CN | disclosed |