Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5463779 | 0.78 | ROCK2 (0.78) | ROCK2ROCK1RAB9ANPC1NAMPT | |
| SCHEMBL28472008 | 0.77 | HPGD (0.53) | RAB9ANPC1NAMPTHPGDKCNK3 | |
| SCHEMBL27652921 | 0.73 | KMT2A (0.57) | RAB9ANPC1NAMPTHPGDKCNK3 | |
| SCHEMBL27652922 | 0.73 | PTPN1 (0.61) | RAB9ANPC1NAMPTHPGDKCNK3 | |
| SCHEMBL4481913 | 0.73 | HPGD (0.71) | RAB9ANPC1NAMPTHPGDKCNK3 | |
| SCHEMBL27672996 | 0.73 | KCNK3 (0.57) | RAB9ANPC1NAMPTHPGDKCNK3 | |
| SCHEMBL27652918 | 0.73 | HDAC6 (0.54) | RAB9ANPC1NAMPTHPGDKCNK3 | |
| SCHEMBL27652929 | 0.72 | HPGD (0.76) | RAB9ANPC1NAMPTHPGDKCNK3 | |
| SCHEMBL27652923 | 0.72 | ADORA3 (0.56) | RAB9ANPC1NAMPTHPGDKCNK3 | |
| SCHEMBL27652917 | 0.71 | HDAC6 (0.49) | RAB9ANPC1NAMPTHPGDKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1946395-A | 1H-thieno [2, 3-c ] pyrazole derivatives useful as kinase inhibitors | PHARMACIA ITALIA SPA (IT) | 2007-04-11 | — | — | CN | claimed |
| CN-1946395-A | 1H-thieno [2, 3-c ] pyrazole derivatives useful as kinase inhibitors | PHARMACIA ITALIA SPA (IT) | 2007-04-11 | — | — | CN | disclosed |