Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2770774 | 0.86 | ALDH1A1 (0.50) | KMT2AL3MBTL1ALDH1A1SMN1; SMN2ALOX12 | |
| SCHEMBL2768768 | 0.84 | SMN1; SMN2 (0.44) | KMT2AALDH1A1SMN1; SMN2ALOX12NPC1 | |
| SCHEMBL2770286 | 0.82 | SMN1; SMN2 (0.44) | KMT2AALDH1A1SMN1; SMN2LMNATP53 | |
| SCHEMBL2770294 | 0.81 | SMN1; SMN2 (0.50) | KMT2AL3MBTL1ALDH1A1SMN1; SMN2ALOX12 | |
| SCHEMBL2768680 | 0.81 | MEN1 (0.48) | KMT2AALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2769899 | 0.80 | SMN1; SMN2 (0.49) | KMT2AL3MBTL1ALDH1A1SMN1; SMN2ALOX12 | |
| SCHEMBL2769700 | 0.80 | SMN1; SMN2 (0.49) | KMT2AL3MBTL1ALDH1A1SMN1; SMN2ALOX12 | |
| SCHEMBL2768663 | 0.77 | RAB9A (0.48) | KMT2AL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2767445 | 0.74 | KDM4E (0.56) | KMT2AALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL2786181 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNATP53SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |
| US-20080176915-A1 | Substituted Benzo[d]isoxazol-3-yl Amine Compounds as Analgesics | GRUENENTHAL GMBH (DE) | 2008-07-24 | — | — | US | claimed |
| US-7696238-B2 | Substituted benzo[d]isoxazol-3-yl amine compounds as analgesics | GRUENENTHAL GMBH (DE) | 2010-04-13 | — | — | US | disclosed |
| US-20080176915-A1 | Substituted Benzo[d]isoxazol-3-yl Amine Compounds as Analgesics | GRUENENTHAL GMBH (DE) | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176915-A1 | Substituted Benzo[d]isoxazol-3-yl Amine Compounds as Analgesics | KCNQ1, KCNQ2, KCNQ3 | KMT2A 197/4885L3MBTL1 1736/4885ALDH1A1 1965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.