Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 3/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27675196 | 0.87 | CREBBP (0.52) | CREBBPEP300MAOBALDH1A1LMNA | |
| SCHEMBL27693521 | 0.86 | BRD4 (0.48) | CREBBPBRD4ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL27693487 | 0.84 | LMNA (0.51) | CREBBPEP300MAOBALDH1A1SMN1; SMN2 | |
| SCHEMBL27693516 | 0.84 | CREBBP (0.61) | CREBBPEP300MAOB | |
| SCHEMBL27693567 | 0.83 | CREBBP (0.47) | CREBBPEP300MAOBALDH1A1LMNA | |
| SCHEMBL27675089 | 0.83 | CA1 (0.51) | CREBBPEP300ALDH1A1 | |
| SCHEMBL27675227 | 0.82 | CFTR (0.48) | CREBBPEP300MAOBALDH1A1SMN1; SMN2 | |
| SCHEMBL27693586 | 0.82 | MAOB (0.60) | CREBBPEP300MAOBALDH1A1LMNA | |
| SCHEMBL27693520 | 0.82 | CASP3 (0.52) | CREBBPEP300ALDH1A1SMN1; SMN2CHRM1 | |
| SCHEMBL27675135 | 0.81 | CREBBP (0.54) | CREBBPEP300MAOBLMNACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101891680-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-10-29 | — | — | CN | disclosed |
| CN-101935301-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2013-10-16 | — | — | CN | disclosed |
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |