Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693573 | 0.89 | CASP3 (0.53) | NPSR1L3MBTL1MAPTALDH1A1USP2 | |
| SCHEMBL27675288 | 0.87 | TSHR (0.53) | NPSR1MAPTTSHRALDH1A1KDM4E | |
| SCHEMBL28768803 | 0.79 | CNR2 (0.51) | MAPTTSHRALDH1A1KDM4EUSP2 | |
| SCHEMBL27693495 | 0.79 | LMNA (0.49) | MAPTALDH1A1KDM4EKMT2ALMNA | |
| SCHEMBL27675206 | 0.78 | KDM4E (0.48) | MAPTALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL27693559 | 0.78 | KDM4E (0.51) | L3MBTL1MAPTALDH1A1KDM4EHTT | |
| SCHEMBL27693542 | 0.77 | CNR2 (0.45) | MAPTALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL27693503 | 0.77 | CFTR (0.47) | ALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL27693487 | 0.77 | LMNA (0.51) | TSHRALDH1A1KDM4EUSP2HTT | |
| SCHEMBL28763089 | 0.76 | CFTR (0.48) | ALDH1A1KDM4EKMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |