Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Chlorobenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.50 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | GABBR2 | O75899 | 4/20 | 0.47 |
| ▸ | GABBR1 | Q9UBS5 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorobenzene SCHEMBL11769266 | 0.98 | TSHR (0.52) | TSHRGLRA1SLC6A9OR51E2CES2 | |
| Chlorobenzene SCHEMBL28004769 | 0.95 | TSHR (0.50) | TSHRGLRA1SLC6A9OR51E2CES2 | |
| Chlorobenzene SCHEMBL27931356 | 0.88 | TSHR (0.52) | TSHRCES2CES1GABBR2GABBR1 | |
| Chlorobenzene SCHEMBL27826332 | 0.88 | TSHR (0.42) | TSHRGLRA1SLC6A9OR51E2CES2 | |
| Chlorobenzene SCHEMBL28847229 | 0.84 | TSHR (0.48) | TSHRCES2CES1GABBR2GABBR1 | |
| Succinic Acid SCHEMBL27643151 | 0.82 | TSHR (0.58) | TSHRCES2CES1LMNACYP1A2 | |
| Chlorobenzene SCHEMBL3005502 | 0.82 | TSHR (0.58) | TSHRCES2CES1CYP1A2KMT2A | |
| Chlorobenzene SCHEMBL27488158 | 0.81 | TSHR (0.65) | TSHRCES2CES1LMNACYP3A4 | |
| Chlorobenzene SCHEMBL9576941 | 0.81 | TSHR (0.65) | TSHRCES2CES1LMNACYP3A4 | |
| Chlorobenzene SCHEMBL29172530 | 0.81 | TSHR (0.73) | TSHRCES2CES1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 228 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118108672-A | O-chlorophenylglycine synthesis intermediate and detection method of o-chlorophenylglycine | 抚顺顺能化工有限公司 | 2024-05-31 | — | — | CN | claimed |
| CN-117645578-A | Preparation method of chlorfenapyr intermediate | 永农生物科学有限公司 | 2024-03-05 | — | — | CN | claimed |
| CN-117007695-A | Analysis method for determining content of potential genotoxic impurities in o-chlorophenylglycine | 苏州正济医药研究有限公司 | 2023-11-07 | — | — | CN | claimed |
| CN-219744741-U | Chlorophenylglycine powder tail gas treatment device | 山东亿嘉农化有限公司 | 2023-09-26 | — | — | CN | claimed |
| CN-114507650-B | Leucine dehydrogenase mutant and application thereof in synthesis of (S) -o-chlorophenylglycine | 浙江工业大学 | 2023-09-05 | — | — | CN | claimed |
| CN-115784914-B | Preparation method of o-chlorophenylglycine | 石家庄中硕科技有限公司 | 2023-05-12 | — | — | CN | claimed |
| CN-218329139-U | Drying equipment is used in production of p chlorobenzene glycine | 河北泽硕药业科技有限公司 | 2023-01-17 | — | — | CN | claimed |
| CN-218307945-U | Synthesis device for preparing o-chlorobenzene glycine intermediate | 抚顺顺能化工有限公司 | 2023-01-17 | — | — | CN | claimed |
| CN-218248843-U | Purification device for preparing p-chlorobenzene glycine | 石家庄中硕科技有限公司 | 2023-01-10 | — | — | CN | claimed |
| CN-114538685-B | Process for removing low-boiling organic matters in high-concentration wastewater | 江苏万邦达环保科技有限公司 | 2022-12-02 | — | — | CN | claimed |
| CN-101864464-B | Chemical-enzyme method for preparing (S)-2-chlorophenyl glycine methyl ester clopidogrel chiral intermediate | CHONGQING CHIRAL BIOCATALYSIS TECHNOLOGY CO LTD | 2012-10-10 | — | — | CN | claimed |
| CN-102432517-A | Method for producing chlorfenapyr technical | SHANDONG YIJIA AGRICULTURE CHEMICALS CO LTD | 2012-05-02 | — | — | CN | claimed |
| CN-102320986-A | Preparation method for clopidogrel intermediate | WUHAN WUYAO TECHNOLOGY CO LTD | 2012-01-18 | — | — | CN | claimed |
| CN-101906032-A | Method for recycling L-(+)-tartaric acid | UNIV EAST CHINA SCIENCE & TECH | 2010-12-08 | — | — | CN | claimed |
| CN-101864464-A | Chemical-enzyme method for preparing (S)-2-chlorophenyl glycine methyl ester clopidogrel chiral intermediate | CHONGQING CHIRAL BIOCATALYSIS TECHNOLOGY CO LTD | 2010-10-20 | — | — | CN | claimed |
| CN-101787032-A | Novel method for preparing clopidogrel and slat thereof | WUXI HOWFOND PHARMACEUTICAL CO | 2010-07-28 | — | — | CN | claimed |
| CN-101560533-A | Preparation method of S-(+)-o-chlorobenzoyl glycine | SUZHOU LIXIN PHARMACEUTICAL CO (CN) | 2009-10-21 | — | — | CN | claimed |
| CN-100548969-C | A kind of preparation method of o-chlorobenzene glycine | ZHEJIANG PULUO MEDICINE TECHNO (CN) | 2009-10-14 | — | — | CN | claimed |
| CN-101092379-A | Method for synthesizing optically active laevogyrate and dexiotropous camphor sulfonic acid | KANGFUSAIER MEDICINES TECH CO (CN) | 2007-12-26 | — | — | CN | claimed |
| CN-101058547-A | Method of preparing o-chlorophenyl glycine | ZHEJIANG PULUO MEDICINE TECHNO (CN) | 2007-10-24 | — | — | CN | claimed |