Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18982945 | 0.83 | ALDH1A1 (0.37) | ALDH1A1MMP2MMP9MMP8MMP13 | |
| SCHEMBL27850077 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2HIF1ABLMALDH1A1KDM4E | |
| SCHEMBL16553913 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2HIF1ABLMALDH1A1KDM4E | |
| SCHEMBL2844022 | 0.79 | BLM (0.59) | SMN1; SMN2HIF1ABLMALDH1A1KDM4E | |
| SCHEMBL5844669 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2HIF1ABLMALDH1A1KDM4E | |
| SCHEMBL27616082 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2HIF1ABLMALDH1A1KDM4E | |
| SCHEMBL2844025 | 0.79 | BLM (0.59) | SMN1; SMN2HIF1ABLMALDH1A1KDM4E | |
| SCHEMBL4937591 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2HIF1ABLMALDH1A1CYP1A2 | |
| SCHEMBL6464407 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2HIF1ABLMALDH1A1CYP1A2 | |
| SCHEMBL5844647 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2HIF1ABLMALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101010339-B | Human glucagon-like-peptide-1 modulators and their use in treatment of diabetes and related conditions | BRISTOL MYERS SQUIBB CO | 2011-11-09 | — | — | CN | disclosed |
| CN-101010339-A | Human glucagon-like-peptide-1 modulators and their use in treatment of diabetes and related conditions | BRISTOL MYERS SQUIBB CO (US) | 2007-08-01 | — | — | CN | disclosed |