Citric Acid

Citric Acid

SCHEMBL2767900

O=C(O)CC(O)(CC(=O)O)C(=O)O.[Eu]

nearest known ligand 0.94

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Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.41
ALDH1A1 P00352 2/20 0.94
HMGCR P04035 1/20 0.48
CHRM1 P11229 1/20 0.48
TBXA2R P21731 1/20 0.48
ADRA1A P35348 1/20 0.48
TSHR P16473 2/20 0.46
CYP2D6 P10635 2/20 0.46
CYP2C19 P33261 1/20 0.46
HIF1A Q16665 1/20 0.46
ACLY P53396 4/20 0.44
KDM4E B2RXH2 2/20 0.43
LMNA P02545 2/20 0.43
MAPT P10636 1/20 0.43
ALOX15 P16050 1/20 0.43
SLC13A5 Q86YT5 4/20 0.42
CPT2 P23786 1/20 0.42
CYP1A2 P05177 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL6889857 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL28641702 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL3417188 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL10896997 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL1332229 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL725546 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL1331942 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL240402 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL842 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL4958371 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104694121-B A kind of preparation method of the carbon quantum dot composite of rare earth doped europium 常州大学 2016-06-29 CN claimed
CN-104694121-A Preparation method of europium-doped carbon quantum dot composite material UNIV CHANGZHOU 2015-06-10 CN claimed
US-4948527-A Method of making europium activated yttrium oxide phosphor GTE PRODUCTS CORPORATION (US) 1990-08-14 US claimed
CN-106590631-B A kind of rare earth mixing with nano calcium citrate fluorescent powder and preparation method thereof 成都理工大学 2019-03-01 CN disclosed
CN-107722971-A A kind of rear-earth-doped zinc citrate fluorescent material 成都理工大学 2018-02-23 CN disclosed
CN-106590631-A Rare earth doped nanometer calcium citrate fluorescent powder and preparation method thereof 成都理工大学 2017-04-26 CN disclosed
CN-104694121-B A kind of preparation method of the carbon quantum dot composite of rare earth doped europium 常州大学 2016-06-29 CN disclosed
CN-104694121-B A kind of preparation method of the carbon quantum dot composite of rare earth doped europium 常州大学 2016-06-29 CN disclosed
CN-104694121-A Preparation method of europium-doped carbon quantum dot composite material UNIV CHANGZHOU 2015-06-10 CN disclosed
CN-101796047-B Luminescent lanthanide (III) chelates, chelating agents and conjugates derived thereof WALLAC OY 2014-12-03 CN disclosed
EP-0985007-B2 OXYGEN-CONTAINING PHOSPHOR POWDERS, METHODS FOR MAKING PHOSPHOR POWDERS AND DEVICES INCORPORATING SAME CABOT CORP (US) 2010-11-03 EP disclosed
US-6210604-B1 FOR X-RAY IMAGE INTENSIFIERS SUPERIOR MICROPOWDERS LLC 2001-04-03 US disclosed
US-6180029-B1 BATCH PROCESSING; GENERATING AEROSOL, HETAING SUPERIOR MICROPOWDERS LLC 2001-01-30 US disclosed
EP-0985007-A1 OXYGEN-CONTAINING PHOSPHOR POWDERS, METHODS FOR MAKING PHOSPHOR POWDERS AND DEVICES INCORPORATING SAME Superior Micropowders LLC (US) 2000-03-15 EP disclosed
WO-2000012649-A1 PHOSPHOR POWDERS, METHODS FOR MAKING PHOSPHOR POWDERS AND DEVICES INCORPORATING SAME SUPERIOR MICROPOWDERS LLC (US) 2000-03-09 WO disclosed
WO-1998037165-A1 OXYGEN-CONTAINING PHOSPHOR POWDERS, METHODS FOR MAKING PHOSPHOR POWDERS AND DEVICES INCORPORATING SAME SUPERIOR MICROPOWDERS LLC (US) 1998-08-27 WO disclosed
US-4948527-A Method of making europium activated yttrium oxide phosphor GTE PRODUCTS CORPORATION (US) 1990-08-14 US disclosed
US-4948527-A Method of making europium activated yttrium oxide phosphor GTE PRODUCTS CORPORATION (US) 1990-08-14 US disclosed
EP-0378652-A1 OLIGONUCLEOTIDE HYBRIDIZATION PROBES AND MEANS FOR THE SYNTHESIS OF THE MOST PREFERRED PROBES WALLAC OY (FI) 1990-07-25 EP disclosed
WO-1990000622-A1 OLIGONUCLEOTIDE HYBRIDIZATION PROBES AND MEANS FOR THE SYNTHESIS OF THE MOST PREFERRED PROBES WALLAC OY (FI) 1990-01-25 WO disclosed