Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14142525 | 0.83 | HSP90AA1 (0.34) | PDE3BPDE3AS1PR1HSP90AA1KDM4E | |
| SCHEMBL14142508 | 0.81 | LMNA (0.36) | PDE3BPDE3AS1PR1HSP90AA1KDM4E | |
| SCHEMBL2674678 | 0.81 | PDE3A (0.39) | PDE3BPDE3AS1PR1HCAR2KDM4E | |
| SCHEMBL2673890 | 0.81 | ALDH1A1 (0.49) | HSP90AA1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL2672600 | 0.80 | SLC9A1 (0.42) | PDE3BPDE3AS1PR1HSP90AA1KDM4E | |
| SCHEMBL2673982 | 0.79 | ALDH1A1 (0.40) | S1PR1HSP90AA1KDM4EALDH1A1HPGD | |
| SCHEMBL2673041 | 0.79 | MAPT (0.36) | PDE3BPDE3AS1PR1HCAR2HSP90AA1 | |
| SCHEMBL14142606 | 0.79 | S1PR1 (0.35) | PDE3BPDE3AS1PR1HCAR2GRIN2D | |
| SCHEMBL2672706 | 0.79 | CYP2A6 (0.49) | PDE3BPDE3AS1PR1HCAR2KDM4E | |
| SCHEMBL2673527 | 0.79 | ALDH1A1 (0.46) | PDE3BPDE3AS1PR1HCAR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1960975-A | Substituted pyridones as poly (ADP-ribose) polymerase (PARP) inhibitors | AVENTIS PHARMA INC (US) | 2007-05-09 | — | — | CN | claimed |
| CN-1960975-A | Substituted pyridones as poly (ADP-ribose) polymerase (PARP) inhibitors | AVENTIS PHARMA INC (US) | 2007-05-09 | — | — | CN | disclosed |