Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27593507 | 0.79 | CHRM2 (0.39) | CHRM2CHRM1LMNAKMT2AALDH1A1 | |
| SCHEMBL28751217 | 0.78 | L3MBTL1 (0.49) | LMNAKMT2AALDH1A1TSHRKDM4E | |
| SCHEMBL27593641 | 0.76 | ALDH1A1 (0.39) | CHRM2CHRM1LMNAKMT2AALDH1A1 | |
| SCHEMBL27788104 | 0.76 | CHRM2 (0.50) | CHRM2CHRM1TSHRHTR2AHTR2C | |
| SCHEMBL27845916 | 0.73 | SMN1; SMN2 (0.40) | CHRM2CHRM1KMT2AALDH1A1TSHR | |
| SCHEMBL28764307 | 0.72 | GCK (0.40) | CHRM2CHRM1ALDH1A1 | |
| SCHEMBL27951598 | 0.71 | CHRM2 (0.36) | CHRM2CHRM1KMT2AALDH1A1TSHR | |
| SCHEMBL28813536 | 0.71 | ALDH1A1 (0.36) | CHRM2CHRM1LMNAKMT2AALDH1A1 | |
| SCHEMBL27572409 | 0.70 | CHRM2 (0.36) | CHRM2CHRM1KMT2AALDH1A1 | |
| SCHEMBL27605812 | 0.69 | PARG (0.40) | CHRM2CHRM1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1960995-B | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful in the treatment of type 2 diabetes | NOVARTIS AG | 2010-12-08 | — | — | CN | disclosed |
| CN-101273015-A | 3-cyclyl-2- (4-sulfamo yl-phenyl) -N-cyclyl-propionamide derivatives useful in the treatment of impaired glucose tolerance and diabetes | NOVARTIS AG (CH) | 2008-09-24 | — | — | CN | disclosed |
| CN-1960995-A | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful the treatment of type 2 diabetes | NOVARTIS AG (CH) | 2007-05-09 | — | — | CN | disclosed |