Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | CASP7 | P55210 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27682184 | 0.88 | KDM4E (0.36) | KDM4EMAPK1CASP1CASP7ATM | |
| SCHEMBL27682201 | 0.88 | KDM4E (0.36) | KDM4EMAPK1CASP1CASP7ATM | |
| SCHEMBL4778930 | 0.87 | KDM4E (0.43) | KDM4EMAPK1CASP1CASP7ATM | |
| SCHEMBL27682170 | 0.85 | TBXAS1 (0.43) | KDM4EMAPK1CASP1CASP7ATM | |
| SCHEMBL27682223 | 0.84 | MAPT (0.38) | KDM4EMAPK1CASP1CASP7ATM | |
| SCHEMBL4774431 | 0.84 | KDM4E (0.37) | KDM4EMAPK1CASP1CASP7ATM | |
| SCHEMBL4776504 | 0.82 | KDM4E (0.47) | KDM4EMAPK1MAPTALDH1A1HSD17B10 | |
| SCHEMBL27682165 | 0.82 | ADORA2A (0.41) | KDM4EMAPK1CASP1CASP7ATM | |
| SCHEMBL27662635 | 0.82 | PRKAA2 (0.36) | ADORA1ADORA3ADORA2AMDM2PSEN1 | |
| SCHEMBL4770239 | 0.82 | KDM4E (0.39) | KDM4EMAPK1CASP1CASP7ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763528-A1 | PYRAZOLOPYRIDINE DERIVATIVES | Astellas Pharma Inc. (JP) | 2007-03-21 | — | — | EP | claimed |
| WO-2006004188-A1 | PYRAZOLOPYRIDINE DERIVATIVES | ASTELLAS PHARMA INC. (JP) | 2006-01-12 | — | — | WO | claimed |
| CN-1980927-A | Pyrazolopyridine derivatives | ASTELLAS PHARMA INC (JP) | 2007-06-13 | — | — | CN | disclosed |