Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 2/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.31 |
| ▸ | CTSA | P10619 | 1/20 | 0.30 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.30 |
| ▸ | GCGR | P47871 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27683046 | 0.89 | MEN1 (0.36) | SLC6A2SLC6A4KCNH2MEN1POLB | |
| SCHEMBL2072820 | 0.84 | SLC6A2 (0.46) | SLC6A2SLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL2072824 | 0.84 | SLC6A2 (0.46) | SLC6A2SLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL2073879 | 0.74 | CACNA2D1 (0.39) | SLC6A2SLC6A4 | |
| SCHEMBL2073984 | 0.71 | SLC6A2 (0.47) | SLC6A2SLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL2073982 | 0.71 | SLC6A2 (0.47) | SLC6A2SLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL27663375 | 0.70 | ADRA2A (0.35) | SLC6A2SLC6A4NR3C1 | |
| SCHEMBL27663360 | 0.65 | HDAC8 (0.51) | SLC6A2SLC6A4KMT2AGCGR | |
| SCHEMBL27682919 | 0.64 | KMO (0.51) | SLC6A2SLC6A4GCGR | |
| SCHEMBL2074747 | 0.64 | SLC6A4 (0.46) | SLC6A2SLC6A4KCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1993321-A | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | HOFFMANN LA ROCHE (CH) | 2007-07-04 | — | — | CN | disclosed |