Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 18/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | EPHB1 | P54762 | 1/20 | 0.32 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2766679 | 0.89 | IKBKB (0.46) | IKBKB | |
| SCHEMBL2766834 | 0.86 | IKBKB (0.41) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL3037384 | 0.85 | IKBKB (0.48) | IKBKB | |
| SCHEMBL2767729 | 0.80 | CHUK (0.31) | IKBKBPIM1PIM2CHUK | |
| SCHEMBL2767778 | 0.79 | MEN1 (0.33) | — | |
| SCHEMBL2767620 | 0.78 | EGFR (0.36) | — | |
| SCHEMBL3041370 | 0.77 | L3MBTL1 (0.36) | IKBKBCHUK | |
| SCHEMBL2767746 | 0.77 | TBK1 (0.33) | — | |
| SCHEMBL2767074 | 0.76 | IKBKB (0.30) | IKBKBCHUK | |
| SCHEMBL2768532 | 0.76 | NLRP3 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | disclosed |