Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1339464 | 0.77 | POLB (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL27712092 | 0.74 | LMNA (0.34) | LMNAL3MBTL1POLB | |
| SCHEMBL28766755 | 0.74 | PLA2G4A (0.35) | LMNAL3MBTL1 | |
| SCHEMBL2656868 | 0.70 | ADORA2A (0.66) | LMNAL3MBTL1CYP2C9ADORA2ANPC1 | |
| SCHEMBL1341903 | 0.69 | SMN1; SMN2 (0.46) | LMNAL3MBTL1CYP2C9ADORA2ANPC1 | |
| SCHEMBL27631139 | 0.69 | CYP2C9 (0.39) | LMNAL3MBTL1CYP2C9ADORA2ANPC1 | |
| SCHEMBL7142997 | 0.69 | ADORA2A (0.64) | LMNAL3MBTL1CYP2C9ADORA2ANPC1 | |
| SCHEMBL17817590 | 0.69 | ADORA2A (0.64) | LMNAL3MBTL1CYP2C9ADORA2ANPC1 | |
| SCHEMBL27712123 | 0.68 | SMN1; SMN2 (0.45) | LMNAL3MBTL1CYP2C9ADORA2ANPC1 | |
| SCHEMBL1339916 | 0.67 | SMN1; SMN2 (0.48) | LMNACYP2C9NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101130526-B | Aryl carbonyl derivatives as therapeutic agents | NOVO NORDISK AS | 2013-07-10 | — | — | CN | disclosed |
| CN-101130526-A | Aryl carbonyl derivatives as therapeutic agents | NOVO NORDISK AS (DK) | 2008-02-27 | — | — | CN | disclosed |