Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 17/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | PRKCB | P05771 | 1/20 | 0.50 |
| ▸ | PRKCA | P17252 | 1/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.50 |
| ▸ | PRKCH | P24723 | 1/20 | 0.50 |
| ▸ | PRKCI | P41743 | 1/20 | 0.50 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.50 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.50 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.50 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.50 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | ICOSLG | O75144 | 4/20 | 0.43 |
| ▸ | ICOS | Q9Y6W8 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10486739 | 0.82 | ADORA3 (0.64) | CHUKPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL14253008 | 0.76 | CHUK (1.00) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL14253017 | 0.74 | CHUK (0.61) | CHUKADORA3ADORA2AADORA1IKBKB | |
| SCHEMBL14253068 | 0.74 | CHUK (0.76) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL1796756 | 0.74 | CHUK (0.76) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL30342051 | 0.74 | CHUK (0.76) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL2768695 | 0.72 | CHUK (0.67) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL20122795 | 0.72 | CHUK (0.72) | CHUKICOSLGICOSIKBKBPIM1 | |
| SCHEMBL13376951 | 0.71 | CHUK (0.59) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL1799747 | 0.70 | CHUK (0.70) | CHUKICOSLGICOSIKBKBTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268477-B1 | SUBSTITUTED BETA-CARBOLINES WITH IKB-KINASE INHIBITING ACTIVITY | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-04-21 | — | — | EP | disclosed |
| US-7348336-B2 | Substituted β-carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-03-25 | — | — | US | disclosed |
| US-20060166978-A1 | Substituted beta carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH | 2006-07-27 | — | — | US | disclosed |
| US-7026331-B2 | Substituted beta-carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-04-11 | — | — | US | disclosed |
| US-20040110759-A1 | Substituted beta carbolines | AVENTIS PHARMA DEUTSCHLAND GMBH | 2004-06-10 | — | — | US | disclosed |
| US-6627637-B2 | I kappa B kinase inhibitors for treating various disorders including arthritis | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-09-30 | — | — | US | disclosed |
| US-20020099068-A1 | Substituted beta carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2002-07-25 | — | — | US | disclosed |
| EP-1209158-A1 | Substituted beta-carbolines | Aventis Pharma Deutschland GmbH (DE) | 2002-05-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110759-A1 | Substituted beta carbolines | CSNK1A1, CSNK2A1, CSNK2B | CHUK 52/4885PRKD3 162/4885PRKCG 87/4885 |
| US-20020099068-A1 | Substituted beta carbolines | CSNK1A1, CSNK2A1, CSNK2B | CHUK 52/4885PRKD3 162/4885PRKCG 87/4885 |
| US-20060166978-A1 | Substituted beta carbolines | NFKBIA, RELA, IKBKG | CHUK 8/4885PRKD3 215/4885PRKCG 170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.