Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | IDH2 | P48735 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28766753 | 0.92 | LMNA (0.37) | KDM4ELPAR1NPC1GAALMNA | |
| SCHEMBL28770680 | 0.85 | IDH2 (0.33) | LPAR1IDH2LIMK1LIMK2 | |
| SCHEMBL1340992 | 0.83 | MAPT (0.41) | NAMPTSMN1; SMN2LPAR1NPC1GAA | |
| SCHEMBL1343195 | 0.80 | FFAR2 (0.42) | SMN1; SMN2LPAR1GAALMNAMAPK1 | |
| SCHEMBL1341799 | 0.79 | MEN1 (0.42) | SMN1; SMN2LPAR1LMNAIDH2LIMK1 | |
| SCHEMBL1342755 | 0.78 | PKM (0.40) | LPAR1 | |
| SCHEMBL1340565 | 0.77 | NAMPT (0.39) | NAMPTKDM4ESMN1; SMN2LPAR1NPC1 | |
| SCHEMBL1342461 | 0.76 | CCNE1 (0.41) | KDM4ELPAR1NPC1GAAATM | |
| SCHEMBL1343925 | 0.76 | LPAR1 (0.37) | NAMPTKDM4ELPAR1NPC1GAA | |
| SCHEMBL1343028 | 0.76 | MEN1 (0.35) | LPAR1GAAIDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101130526-B | Aryl carbonyl derivatives as therapeutic agents | NOVO NORDISK AS | 2013-07-10 | — | — | CN | disclosed |
| CN-101130526-A | Aryl carbonyl derivatives as therapeutic agents | NOVO NORDISK AS (DK) | 2008-02-27 | — | — | CN | disclosed |