Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 7/20 | 0.43 |
| ▸ | CNR1 | P21554 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | ABHD12 | Q8N2K0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485894 | 0.96 | CXCR2 (0.48) | CXCR2CNR2CNR1ALDH1A1MEN1 | |
| SCHEMBL485837 | 0.94 | ALDH1A1 (0.48) | CXCR2CNR2CNR1ALDH1A1MEN1 | |
| Formic Acid SCHEMBL27713047 | 0.88 | CXCR2 (0.58) | CXCR2CNR2CNR1ALDH1A1MEN1 | |
| Formic Acid SCHEMBL27693212 | 0.88 | CXCR2 (0.50) | CXCR2CNR2CNR1ALDH1A1MEN1 | |
| Formic Acid SCHEMBL27712959 | 0.87 | CNR2 (0.56) | CXCR2CNR2CNR1ALDH1A1MEN1 | |
| Formic Acid SCHEMBL27693263 | 0.87 | MEN1 (0.57) | CXCR2CNR2CNR1ALDH1A1MEN1 | |
| Formic Acid SCHEMBL27693432 | 0.86 | CXCR2 (0.46) | CXCR2CNR2CNR1ALDH1A1MEN1 | |
| Formic Acid SCHEMBL27693230 | 0.85 | DRD4 (0.52) | CXCR2CNR2CNR1ALDH1A1MEN1 | |
| SCHEMBL485699 | 0.84 | CXCR2 (0.62) | CXCR2CNR2CNR1ALDH1A1MEN1 | |
| SCHEMBL486231 | 0.83 | CXCR2 (0.52) | CXCR2CNR2CNR1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | claimed |
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | disclosed |