Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693487 | 0.91 | LMNA (0.51) | CHRM1MAOBHTR6LMNASMN1; SMN2 | |
| SCHEMBL28766931 | 0.88 | CHRM1 (0.52) | CHRM1MAOBHTR6LMNAMAPT | |
| SCHEMBL27675384 | 0.88 | CHRM1 (0.49) | CHRM1MAOBHTR6LMNASMN1; SMN2 | |
| SCHEMBL27693645 | 0.87 | CHRM1 (0.54) | CHRM1LMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL27675310 | 0.87 | CHRM1 (0.54) | CHRM1MAOBLMNAMAPTTHRB | |
| SCHEMBL28766934 | 0.87 | CFTR (0.48) | CHRM1MAOBHTR6LMNAMAPT | |
| SCHEMBL27675381 | 0.87 | CFTR (0.48) | CHRM1MAOBHTR6LMNAMAPT | |
| SCHEMBL27693510 | 0.86 | CHRM1 (0.46) | CHRM1MAOBHTR6LMNAMAPT | |
| SCHEMBL27675257 | 0.85 | CHRM1 (0.55) | CHRM1LMNAKDM4ENAMPT | |
| SCHEMBL27693499 | 0.85 | CHRM1 (0.47) | CHRM1LMNAMAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |