Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693510 | 0.92 | CHRM1 (0.46) | CFTRKMT2AMEN1GFERMAPT | |
| SCHEMBL27693487 | 0.88 | LMNA (0.51) | KMT2AMEN1LMNAALDH1A1CHRM1 | |
| SCHEMBL27693452 | 0.87 | CHRM1 (0.49) | KMT2AMEN1MAPTLMNACHRM1 | |
| SCHEMBL28766931 | 0.87 | CHRM1 (0.52) | KMT2AMEN1MAPTLMNACHRM1 | |
| SCHEMBL27675140 | 0.85 | ALDH1A1 (0.40) | CFTRKMT2AMEN1GFERMAPT | |
| SCHEMBL27675384 | 0.84 | CHRM1 (0.49) | KMT2AMEN1LMNAALDH1A1CHRM1 | |
| SCHEMBL28766934 | 0.84 | CFTR (0.48) | CFTRMAPTLMNACHRM1KDM4E | |
| SCHEMBL27693645 | 0.84 | CHRM1 (0.54) | KMT2AMEN1MAPTLMNAALDH1A1 | |
| SCHEMBL27675310 | 0.84 | CHRM1 (0.54) | CFTRKMT2AMEN1MAPTLMNA | |
| SCHEMBL27675125 | 0.82 | CFTR (0.47) | CFTRKMT2AMEN1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |