Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27675257 | 0.89 | CHRM1 (0.55) | CHRM1LMNA | |
| SCHEMBL27693592 | 0.89 | CHRM1 (0.51) | CHRM1LMNAPOLBKMT2A | |
| SCHEMBL27693645 | 0.88 | CHRM1 (0.54) | CHRM1LMNAMEN1POLBKMT2A | |
| SCHEMBL27693487 | 0.88 | LMNA (0.51) | CHRM1LMNAMEN1POLBKMT2A | |
| SCHEMBL27693452 | 0.87 | CHRM1 (0.49) | CHRM1LMNAMEN1KMT2AMAOB | |
| SCHEMBL27675101 | 0.85 | KMT2A (0.52) | CHRM1LMNAMEN1KMT2AMAPT | |
| SCHEMBL27675186 | 0.84 | CFTR (0.52) | CHRM1LMNAMEN1POLBKMT2A | |
| SCHEMBL28766931 | 0.84 | CHRM1 (0.52) | CHRM1LMNAMEN1POLBKMT2A | |
| SCHEMBL27675384 | 0.84 | CHRM1 (0.49) | CHRM1LMNAMEN1KMT2AMAOB | |
| SCHEMBL28766934 | 0.84 | CFTR (0.48) | CHRM1LMNACFTRMAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |