Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MARS1 | P56192 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21326105 | 0.89 | MARS1 (0.45) | POLBLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4321504 | 0.77 | TSHR (0.53) | POLBLMNAIDO1MEN1KMT2A | |
| SCHEMBL30702088 | 0.77 | MEN1 (0.43) | POLBMEN1KMT2AGAACYP1A2 | |
| SCHEMBL1411887 | 0.77 | MEN1 (0.43) | POLBMEN1KMT2AGAACYP1A2 | |
| SCHEMBL1705227 | 0.76 | NPC1 (0.33) | POLBLMNAMEN1KMT2ATDP1 | |
| SCHEMBL2977343 | 0.75 | GAA (0.54) | POLBLMNAMEN1KMT2AGAA | |
| SCHEMBL22859170 | 0.75 | KMT2A (0.38) | MEN1KMT2ASMN1; SMN2CHRM2ALDH1A1 | |
| SCHEMBL183773 | 0.75 | POLB (0.48) | POLBLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31509729 | 0.74 | MEN1 (0.40) | LMNAMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9621731 | 0.74 | DBH (0.39) | POLBLMNAMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753739-B1 | IMIDAZOL-2-ONE COMPOUNDS USEFUL IN THE TREATMENT OF VARIOUS DISORDERS | GLAXO GROUP LTD (GB) | 2010-04-28 | — | — | EP | disclosed |
| US-7534893-B2 | Imidazol-2-one compounds useful in the treatment of various disorders | GLAXO GROUP LIMITED (GB) | 2009-05-19 | — | — | US | disclosed |
| US-20070249679-A1 | Imidazol-2-One Compounds Useful in the Treatment of Various Disorders | GLAXO GROUP LIMITED (GB) | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249679-A1 | Imidazol-2-One Compounds Useful in the Treatment of Various Disorders | SLC6A4, SLC18A2, SLC18A1 | POLB 4047/4885LMNA 4229/4885IDO1 396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.