Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | RPA1 | P27694 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172166 | 0.80 | PIK3CA (0.45) | PIK3CADAOHDAC3HDAC1HDAC2 | |
| SCHEMBL9514553 | 0.78 | XDH (0.47) | PIK3CADAOHDAC3HDAC1HDAC2 | |
| SCHEMBL1503218 | 0.77 | PIK3CA (0.45) | PIK3CADAOHDAC3HDAC1HDAC2 | |
| SCHEMBL42420 | 0.75 | PIK3CA (0.44) | PIK3CADAOHDAC3HDAC1HDAC2 | |
| SCHEMBL23850015 | 0.74 | TAAR1 (0.47) | PIK3CADAOHDAC3HDAC1HDAC2 | |
| SCHEMBL16388285 | 0.73 | PIK3CA (0.45) | PIK3CADAOHDAC3HDAC1HDAC2 | |
| SCHEMBL27715138 | 0.72 | PNMT (0.52) | ALDH1A1PNMTTAAR1HTTCYP3A4 | |
| SCHEMBL17552701 | 0.71 | PIK3CA (0.44) | PIK3CADAOHDAC3HDAC1HDAC2 | |
| SCHEMBL151278 | 0.71 | PIK3CA (0.44) | PIK3CADAOHDAC3HDAC1HDAC2 | |
| SCHEMBL257081 | 0.71 | TSHR (0.44) | PIK3CADAOHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101107235-B | Morpholines as 5HT2C agonists | HOFFMANN LA ROCHE | 2011-03-16 | — | — | CN | disclosed |
| CN-101107235-A | Morpholines as 5HT2C agonists | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | CN | disclosed |