Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.83 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.74 |
| ▸ | DRD2 | P14416 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 3/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15920946 | 1.00 | KCNH2 (0.83) | KCNH2SIGMAR1DRD2KDM4EGAA | |
| SCHEMBL7594226 | 0.98 | KCNH2 (0.79) | KCNH2SIGMAR1DRD2KDM4EGAA | |
| SCHEMBL155128 | 0.93 | SIGMAR1 (0.79) | KCNH2SIGMAR1DRD2KDM4EGAA | |
| SCHEMBL15690402 | 0.92 | KCNH2 (0.70) | KCNH2SIGMAR1DRD2KDM4EGAA | |
| SCHEMBL4528457 | 0.91 | KCNH2 (1.00) | KCNH2SIGMAR1DRD2CYP2D6HTR1A | |
| SCHEMBL3453669 | 0.85 | DRD2 (1.00) | KCNH2SIGMAR1DRD2CYP2D6CHRNA7 | |
| SCHEMBL5988317 | 0.85 | KCNH2 (0.88) | KCNH2SIGMAR1DRD2CYP2D6CHRNA7 | |
| SCHEMBL10564975 | 0.83 | KDM4E (0.72) | KCNH2SIGMAR1DRD2KDM4EGAA | |
| SCHEMBL7126924 | 0.83 | SIGMAR1 (0.65) | KCNH2SIGMAR1DRD2KDM4EGAA | |
| SCHEMBL5542882 | 0.83 | KDM4E (0.68) | KCNH2SIGMAR1DRD2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101137645-A | Arylpiperazine derivatives for the treatment of neuropsychiatric disorders | UNIV SIENA (IT) | 2008-03-05 | — | — | CN | claimed |
| CN-101137645-A | Arylpiperazine derivatives for the treatment of neuropsychiatric disorders | UNIV SIENA (IT) | 2008-03-05 | — | — | CN | disclosed |