Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.65 |
| ▸ | DRD2 | P14416 | 4/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7127468 | 0.90 | DRD2 (0.80) | SIGMAR1DRD2KCNH2KDM4EGAA | |
| SCHEMBL155128 | 0.90 | SIGMAR1 (0.79) | SIGMAR1DRD2KCNH2KDM4EGAA | |
| SCHEMBL7594226 | 0.85 | KCNH2 (0.79) | SIGMAR1DRD2KCNH2KDM4EGAA | |
| SCHEMBL27695348 | 0.83 | KCNH2 (0.83) | SIGMAR1DRD2KCNH2KDM4EGAA | |
| SCHEMBL15920946 | 0.83 | KCNH2 (0.83) | SIGMAR1DRD2KCNH2KDM4EGAA | |
| SCHEMBL12319455 | 0.83 | CHRNA7 (0.79) | SIGMAR1DRD2KDM4EGAACHRNA7 | |
| SCHEMBL8223307 | 0.80 | KDM4E (0.62) | SIGMAR1DRD2KDM4EGAADRD3 | |
| SCHEMBL29258877 | 0.80 | KDM4E (0.69) | SIGMAR1DRD2KCNH2KDM4EGAA | |
| SCHEMBL10724890 | 0.80 | GAA (0.62) | SIGMAR1DRD2KCNH2KDM4EGAA | |
| SCHEMBL27822324 | 0.80 | SIGMAR1 (0.64) | SIGMAR1DRD2KCNH2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030139394-A1 | Dibenzodiazepine derivatives, their preparation and use | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2003-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139394-A1 | Dibenzodiazepine derivatives, their preparation and use | CYP1B1, DRD1, CYP1A1 | SIGMAR1 194/4885DRD2 10/4885KCNH2 1055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.